Defective Viral Particles and Viral Disease Processes

  title={Defective Viral Particles and Viral Disease Processes},
  author={Alice S. Huang and David Baltimore},
Preparations of many different types of viruses contain defective particles which consist of viral structural proteins and a part of the viral genome. Such particles are capable of specifically interfering with the growth of homologous, standard virus and may play a major part in the evolution of viral diseases. 
Homologous Viral Interference: Induction by RNA from Defective Particles of Vesicular Stomatitis Virus
The viral RNA isolated from the defective particles of vesicular stomatitis virus was capable of interfering with the replication of this virus in chick embryo cells. The data indicate that the
Mumps virus-persistently infected cell cultures release defective interfering virus particles.
Summary Two human cell cultures, HEp-2 and L-41, persistently infected with mumps virus, produced small amounts of slowly replicating small-plaque infectious virus and detectable amounts of defective
Defective and Satellite Plant Viruses
By the term “complete virus” or “normal virus,” it is assumed that a normal virus is capable of performing certain functions thereby inducing production of new proteins in the infected cell which are essential for virus replication.
Origin and replication of defective interfering particles.
  • J. Perrault
  • Computer Science
    Current topics in microbiology and immunology
  • 1981
Defective interfering virus (DI) particles represent a major controlling element of virus replication and only amplify to interfering levels when the parent helper vims is abundant.
Variant and Defective Interfering Parvoviruses
Growth of viruses in eukaryotic cells frequently results in production of variant viruses having altered or deleted genome sequences. Detailed study of these variants provides important information
Defective interfering particles of Sindbis virus do not interfere with the homologous virus obtained from persistently infected BHK cells but do interfere with Semliki Forest virus
Defective interfering particles derived from wild-type Sindbis virus no longer interfere with the infectious virus cloned from BHK cells persistently infected with Sindbis virus for 16 months. These
Defective interfering virus particles and their biological functions.
  • C. Kang
  • Biology
    Advances in experimental medicine and biology
  • 1981
A brief summary of the properties and the biological significance of DI particles in the outcome of natural viral infections will be presented here.
Persistent infection of tissue culture cells by RNA viruses
In this paper, the characteristics of cultured cells persistently infected with RNA viruses, other than leuko viruses are described. The roles that the host cell, interferon, virus mutants and
Homotypic and Heterotypic Interference by Defective Particles of Vesicular Stomatitis Virus
Defective particles can serve as templates for their replication by helper infectious virus and are capable of homotypic interference, but only the larger “long T” particle is capable of heterotyping interference.


It is suggested that the incomplete forms of incomplete fowl plague virus are lacking in identical pieces of their genome, but contain that part of their RNA which codes for ‘early protein’, S-antigen and haemagglutinin.
Some properties of the transmissible interfering component of vesicular stomatitis virus preparations.
SUMMARY: In vesicular stomatitis virus inocula containing the transmissible interfering component (T) an exponential relation, at low doses, between inoculum concentration and virus yield suggested