Defective Viral Particles and Viral Disease Processes

@article{Huang1970DefectiveVP,
  title={Defective Viral Particles and Viral Disease Processes},
  author={Alice S. Huang and David Baltimore},
  journal={Nature},
  year={1970},
  volume={226},
  pages={325-327}
}
Preparations of many different types of viruses contain defective particles which consist of viral structural proteins and a part of the viral genome. Such particles are capable of specifically interfering with the growth of homologous, standard virus and may play a major part in the evolution of viral diseases. 
Homologous Viral Interference: Induction by RNA from Defective Particles of Vesicular Stomatitis Virus
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    Advances in experimental medicine and biology
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Homotypic and Heterotypic Interference by Defective Particles of Vesicular Stomatitis Virus
TLDR
Defective particles can serve as templates for their replication by helper infectious virus and are capable of homotypic interference, but only the larger “long T” particle is capable of heterotyping interference.
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