Defective Viral Particles and Viral Disease Processes

@article{Huang1970DefectiveVP,
  title={Defective Viral Particles and Viral Disease Processes},
  author={Alice S. Huang and David Baltimore},
  journal={Nature},
  year={1970},
  volume={226},
  pages={325-327}
}
Preparations of many different types of viruses contain defective particles which consist of viral structural proteins and a part of the viral genome. Such particles are capable of specifically interfering with the growth of homologous, standard virus and may play a major part in the evolution of viral diseases. 
Homologous Viral Interference: Induction by RNA from Defective Particles of Vesicular Stomatitis Virus
The viral RNA isolated from the defective particles of vesicular stomatitis virus was capable of interfering with the replication of this virus in chick embryo cells. The data indicate that the
Mumps virus-persistently infected cell cultures release defective interfering virus particles.
Summary Two human cell cultures, HEp-2 and L-41, persistently infected with mumps virus, produced small amounts of slowly replicating small-plaque infectious virus and detectable amounts of defective
Origin and replication of defective interfering particles.
  • J. Perrault
  • Computer Science
    Current topics in microbiology and immunology
  • 1981
TLDR
Defective interfering virus (DI) particles represent a major controlling element of virus replication and only amplify to interfering levels when the parent helper vims is abundant.
Variant and Defective Interfering Parvoviruses
Growth of viruses in eukaryotic cells frequently results in production of variant viruses having altered or deleted genome sequences. Detailed study of these variants provides important information
Defective interfering particles of Sindbis virus do not interfere with the homologous virus obtained from persistently infected BHK cells but do interfere with Semliki Forest virus
Defective interfering particles derived from wild-type Sindbis virus no longer interfere with the infectious virus cloned from BHK cells persistently infected with Sindbis virus for 16 months. These
Homotypic and Heterotypic Interference by Defective Particles of Vesicular Stomatitis Virus
TLDR
Defective particles can serve as templates for their replication by helper infectious virus and are capable of homotypic interference, but only the larger “long T” particle is capable of heterotyping interference.
The role of defective interfering particles in persistent infection of Vero cells by measles virus.
TLDR
Measles virus released from a persistently infected Vero cell line at the 93rd passage had properties similar to the undiluted passage virus that generated persistent infections.
Persistent measles virus infection in vitro and in man.
TLDR
The characteristics of cell lines persistently infected with measles virus are described and evidence for measles virus infection in multiple sclerosis, Paget's disease, and systemic lupus erythematosus is discussed.
Defective virus RNA synthesis and production of incomplete influenza virus in chick embryo cells.
  • D. Nayak
  • Biology
    The Journal of general virology
  • 1972
TLDR
It is concluded that the formation of von Magnus virus in chick embryo cells is due to a defective synthesis of virus RNA components and not due toA defective assembly and release of virus particles.
Defective Virus R N A Synthesis and Production of Incomplete Influenza Virus in Chick Embryo Cells
  • Biology
  • 2007
TLDR
It is concluded that the formation of von Magnus virus in chick embryo cells is due to a defective synthesis of virus RNA components and not due toA defective assembly and release of virus particles.
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SUMMARY: In vesicular stomatitis virus inocula containing the transmissible interfering component (T) an exponential relation, at low doses, between inoculum concentration and virus yield suggested
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