Defective Tbx2-dependent patterning of the atrioventricular canal myocardium causes accessory pathway formation in mice.

@article{Aanhaanen2011DefectiveTP,
  title={Defective Tbx2-dependent patterning of the atrioventricular canal myocardium causes accessory pathway formation in mice.},
  author={W. T. J. Aanhaanen and Bastiaan J. Boukens and Aleksander Sizarov and Vincent Wakker and Corrie de Gier-de Vries and Antoni CG van Ginneken and Antoon F. M. Moorman and Ruben Coronel and Vincent M Christoffels},
  journal={The Journal of clinical investigation},
  year={2011},
  volume={121 2},
  pages={534-44}
}
Ventricular preexcitation, a feature of Wolff-Parkinson-White syndrome, is caused by accessory myocardial pathways that bypass the annulus fibrosus. This condition increases the risk of atrioventricular tachycardia and, in the presence of atrial fibrillation, sudden death. The developmental mechanisms underlying accessory pathway formation are poorly understood but are thought to primarily involve malformation of the annulus fibrosus. Before birth, slowly conducting atrioventricular myocardium… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 31 extracted citations

Signaling and transcriptional networks in heart development and regeneration.

Cold Spring Harbor perspectives in biology • 2013
View 6 Excerpts
Highly Influenced

Development and Function of the Cardiac Conduction System in Health and Disease

Journal of cardiovascular development and disease • 2017
View 4 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 51 references

Development of the pacemaker tissues of the heart

MM Kreuzberg
CircRes . • 2010

Generation of mice with a conditional null alíele forTbx 2

R Agah, PA Frenkel, BA French, LH Michael, Schneider
Genesis . • 2010

, etal . 20 pl 2 . 3 microdeletion predisposes to WolfF - Parkinson - White syndrome with variable neu - rocognitivedeficits

Z Yang
2009

A 8 . 26 Mb deletion in 6 ql 6 and a 4 . 95 Mb deletion in 20 pl 2 including JAGl and BMP 2 in a patient with Alagille syndrome and WolfF - Parkinson - White syndrome

LalaniSR.
EurJMedGenet • 2008

Abnormal conduction and morphology in the atriovenrricular node of mice with atrioventricular canal - targeted deletion of Alk 3 / Bmpr la recep

DM Srroud
Circulation . • 2008

Similar Papers

Loading similar papers…