Defective Tbx2-dependent patterning of the atrioventricular canal myocardium causes accessory pathway formation in mice.

  title={Defective Tbx2-dependent patterning of the atrioventricular canal myocardium causes accessory pathway formation in mice.},
  author={W. T. J. Aanhaanen and Bastiaan J. Boukens and Aleksander Sizarov and Vincent Wakker and Corrie de Gier-de Vries and Antoni CG van Ginneken and Antoon F. M. Moorman and Ruben Coronel and Vincent M Christoffels},
  journal={The Journal of clinical investigation},
  volume={121 2},
Ventricular preexcitation, a feature of Wolff-Parkinson-White syndrome, is caused by accessory myocardial pathways that bypass the annulus fibrosus. This condition increases the risk of atrioventricular tachycardia and, in the presence of atrial fibrillation, sudden death. The developmental mechanisms underlying accessory pathway formation are poorly understood but are thought to primarily involve malformation of the annulus fibrosus. Before birth, slowly conducting atrioventricular myocardium… CONTINUE READING


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