Defective T cell differentiation in the absence of Jnk1.

@article{Dong1998DefectiveTC,
  title={Defective T cell differentiation in the absence of Jnk1.},
  author={Chen Dong and Derek Yang and Mark Wysk and Alan J. Whitmarsh and Roger J Davis and Richard A Flavell},
  journal={Science},
  year={1998},
  volume={282 5396},
  pages={2092-5}
}
The c-Jun NH2-terminal kinase (JNK) signaling pathway has been implicated in the immune response that is mediated by the activation and differentiation of CD4 helper T (TH) cells into TH1 and TH2 effector cells. JNK activity observed in wild-type activated TH cells was severely reduced in TH cells from Jnk1-/- mice. The Jnk1-/- T cells hyperproliferated, exhibited decreased activation-induced cell death, and preferentially differentiated to TH2 cells. The enhanced production of TH2 cytokines by… CONTINUE READING
Highly Influential
This paper has highly influenced 21 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

From This Paper

Topics from this paper.
253 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 253 extracted citations

Similar Papers

Loading similar papers…