Defective PAX4 R192H transcriptional repressor activities associated with maturity onset diabetes of the young and early onset-age of type 2 diabetes.

@article{Kooptiwut2012DefectivePR,
  title={Defective PAX4 R192H transcriptional repressor activities associated with maturity onset diabetes of the young and early onset-age of type 2 diabetes.},
  author={Suwattanee Kooptiwut and Nattachet Plengvidhya and Titikan Chukijrungroat and Jatuporn Sujjitjoon and Namoiy Semprasert and Hiroto Furuta and Pa-Thai Yenchitsomanus},
  journal={Journal of diabetes and its complications},
  year={2012},
  volume={26 4},
  pages={
          343-7
        }
}
AIMS PAX4 R192H polymorphism was reported to be associated with maturity onset diabetes of the young (MODY) and early onset-age of type 2 diabetes (T2D). This study aimed to evaluate transcriptional repression activity of PAX4 R192H polymorphism on its target promoters comparing with wild-type PAX4. METHODS Wild-type PAX4 and PAX4 R192H proteins were expressed in vitro and the cell compartmentalization of each protein was examined after transfection of the plasmid constructs into βTC3 cells… CONTINUE READING
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