Defective Osteogenic Differentiation in the Development of Osteosarcoma

  title={Defective Osteogenic Differentiation in the Development of Osteosarcoma},
  author={Eric R. Wagner and Gaurav Aman Luther and Gaohui Zhu and Qingyang Luo and Qiong Shi and Stephanie H Kim and Jian-Li Gao and Enyi Huang and Yanhong Gao and Ke Yang and Linyuan Wang and Chad M Teven and Xiaoji Luo and Xing Liu and Mi Li and N. Q. Hu and Yuxi Su and Yang Bi and Bai-Cheng He and Ni Tang and Jinyong Luo and Liang Chen and Guowei Zuo and Richard Rames and Rex C. Haydon and Hue H. Luu and Tong-Chuan He},
Osteosarcoma (OS) is associated with poor prognosis due to its high incidence of metastasis and chemoresistance. It often arises in areas of rapid bone growth in long bones during the adolescent growth spurt. Although certain genetic conditions and alterations increase the risk of developing OS, the molecular pathogenesis is poorly understood. Recently, defects in differentiation have been linked to cancers, as they are associated with high cell proliferation. Treatments overcoming these… CONTINUE READING

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