Defective Neuromuscular Synaptogenesis in Agrin-Deficient Mutant Mice

@article{Gautam1996DefectiveNS,
  title={Defective Neuromuscular Synaptogenesis in Agrin-Deficient Mutant Mice},
  author={Medha Gautam and Peter G. Noakes and Lisa M Moscoso and Fabio Rupp and Richard H. Scheller and John Paul Merlie and Joshua R Sanes},
  journal={Cell},
  year={1996},
  volume={85},
  pages={525-535}
}
During neuromuscular synapse formation, motor axons induce clustering of acetylcholine receptors (AChRs) in the muscle fiber membrane. The protein agrin, originally isolated from the basal lamina of the synaptic cleft, is synthesized and secreted by motoneurons and triggers formation of AChR clusters on cultured myotubes. We show here postsynaptic AChR aggregates are markedly reduced in number, size, and density in muscles of agrin-deficient mutant mice. These results support the hypothesis… CONTINUE READING
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References

Publications referenced by this paper.
Showing 1-10 of 51 references

Agrin is a heparan sulfate proteoglycan.

The Journal of biological chemistry • 1995
View 4 Excerpts
Highly Influenced

The role of agrin in synapse formation.

Annual review of neuroscience • 1995
View 10 Excerpts
Highly Influenced

The agrin hypothesis.

Cold Spring Harbor symposia on quantitative biology • 1990
View 4 Excerpts
Highly Influenced

Derivation of completely cell culture-derived mice from early-passage embryonic stem cells.

Proceedings of the National Academy of Sciences of the United States of America • 1993
View 3 Excerpts
Highly Influenced

Molecular events in synaptospliced forms of agrin

R. J. Bloch, D. W. Pumplin
Neuron 11, 479–490. • 1988
View 4 Excerpts
Highly Influenced

Redistribution of acetylcholine receptors on developing rat myotubes.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 1984
View 5 Excerpts
Highly Influenced

Embryonic growth and innervation of rat skeletal muscles. II. Neural regulation of muscle cholinesterase.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences • 1981
View 3 Excerpts
Highly Influenced

The formation of neurotylcholine receptor clusters

M. R. Bennett, A. G. Pettigrew
Phil. Trans. Soc. Lond. B 293, 287–314. • 1976
View 4 Excerpts
Highly Influenced

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