Defective Neurogenesis in Citron Kinase Knockout Mice by Altered Cytokinesis and Massive Apoptosis

@article{Cunto2000DefectiveNI,
  title={Defective Neurogenesis in Citron Kinase Knockout Mice by Altered Cytokinesis and Massive Apoptosis},
  author={Ferdinando Di Cunto and Sara Imarisio and Emilio Hirsch and Vania Broccoli and Alessandro Bulfone and Antonio Migheli and Cristiana Atzori and E. Turco and Roberta Triolo and Gian Paolo Dotto and Lorenzo Silengo and Fiorella Altruda},
  journal={Neuron},
  year={2000},
  volume={28},
  pages={115-127}
}
Citron-kinase (Citron-K) has been proposed by in vitro studies as a crucial effector of Rho in regulation of cytokinesis. To further investigate in vivo its biologic functions, we have inactivated Citron-K gene in mice by homologous recombination. Citron-K-/- mice grow at slower rates, are severely ataxic, and die before adulthood as a consequence of fatal seizures. Their brains display defective neurogenesis, with depletion of specific neuronal populations. These abnormalities arise during… CONTINUE READING

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