Defective NF-κB activation in virus-infected neuronal cells is restored by genetic complementation

@article{Fang2002DefectiveNA,
  title={Defective NF-κB activation in virus-infected neuronal cells is restored by genetic complementation},
  author={Yu-Yan Fang and Zan-Min Song and Tao Wu and Abhijit Raha and Dhananjaya V. Kalvakolanu and Suhayl Dhib-Jalbut},
  journal={Journal of NeuroVirology},
  year={2002},
  volume={8},
  pages={459-463}
}
The interferon-beta (IFNβ) gene is not inducible in neuronal cells in response to measles virus (MV) due to lack of nuclear factor kappa B (NF-κB) activation. NF-κB is normally sequestered in the cytoplasm by an inhibitor (IκBα). Previously, the authors demonstrated that the failure to activate neuronal NF-κB by MV was due to the inability to phosphorylate and degrade its inhibitor, IκBα. Here the authors demonstrate that transient transfection of a brain cDNA library into neuronal cells… CONTINUE READING

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  • S Dhib-Jalbut, KP Johnson
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