Defective N-oxidation of sparteine in man: A new pharmacogenetic defect

  title={Defective N-oxidation of sparteine in man: A new pharmacogenetic defect},
  author={Michel F Eichelbaum and N. Spannbrucker and Barbara Steincke and Hans J. Dengler},
  journal={European Journal of Clinical Pharmacology},
Sparteine, an antiarrhythmic and oxytocic drug, is metabolised by N1-oxidation. The sparteine-N1-oxide rearranges with loss of water to 2- and 5-dehydrosparteine. 18 (i. e., 5%) out of 360 subjects were unable to metabolise the drug. These persons, who were designated as nonmetabolisers, excreted almost 100% of the administered dose in urine as unchanged drug. The defective metabolism of sparteine was found to have a genetic basis. Sparteine-N1-oxidation appears to be determined by two allelic… CONTINUE READING

From This Paper

Figures, tables, results, connections, and topics extracted from this paper.
135 Extracted Citations
14 Extracted References
Similar Papers

Referenced Papers

Publications referenced by this paper.
Showing 1-10 of 14 references

Polymorphismen und Defekte des Arzneimittelstoffwechsels als Ursache toxischer Reaktionen

  • H. J. Dengler, M. Eichelbaum
  • Arzneim. Forsch. (Drug Res.) 27, 1836-1844
  • 1977

Lack of N - oxidation of sparteine in certain healthy subjects

  • M. Eichelbaum, N. Spannbrucker, H. J. Dengler
  • Sixth International Congress of Pharmacology
  • 1975

Pharmakogenetik : Variabilit ~ t yon Arz - neimittelwirkung und Stoffwechselreaktion

  • H. W. Goedde
  • Internist
  • 1974

Zur Chemie des Sparteins

  • F. Binnig
  • Arzneim. Forsch. (Drug Res.) 24, 752-753
  • 1974

Similar Papers

Loading similar papers…