Defective N-oxidation of sparteine in man: A new pharmacogenetic defect

@article{Eichelbaum1979DefectiveNO,
  title={Defective N-oxidation of sparteine in man: A new pharmacogenetic defect},
  author={Michel F Eichelbaum and N. Spannbrucker and Barbara Steincke and Hans J. Dengler},
  journal={European Journal of Clinical Pharmacology},
  year={1979},
  volume={16},
  pages={183-187}
}
Sparteine, an antiarrhythmic and oxytocic drug, is metabolised by N1-oxidation. The sparteine-N1-oxide rearranges with loss of water to 2- and 5-dehydrosparteine. 18 (i. e., 5%) out of 360 subjects were unable to metabolise the drug. These persons, who were designated as nonmetabolisers, excreted almost 100% of the administered dose in urine as unchanged drug. The defective metabolism of sparteine was found to have a genetic basis. Sparteine-N1-oxidation appears to be determined by two allelic… CONTINUE READING

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