Defective Lymphotoxin-β Receptor-Induced NF-κB Transcriptional Activity in NIK-Deficient Mice

@article{Yin2001DefectiveLR,
  title={Defective Lymphotoxin-$\beta$ Receptor-Induced NF-$\kappa$B Transcriptional Activity in NIK-Deficient Mice},
  author={Li Yin and Lin Wu and Holger Wesche and Cora D. Arthur and J. Michael White and David Norman Van Goeddel and Robert D. Schreiber},
  journal={Science},
  year={2001},
  volume={291},
  pages={2162 - 2165}
}
The role of NF-κB–inducing kinase (NIK) in cytokine signaling remains controversial. To identify the physiologic functions of NIK, we disrupted the NIK locus by gene targeting. Although NIK–/– mice displayed abnormalities in both lymphoid tissue development and antibody responses, NIK–/– cells manifested normal NF-κB DNA binding activity when treated with a variety of cytokines, including tumor necrosis factor (TNF), interleukin-1 (IL-1), and lymphotoxin-β (LTβ). However, NIK was selectively… 
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