Defective Lymphotoxin-β Receptor-Induced NF-κB Transcriptional Activity in NIK-Deficient Mice

@article{Yin2001DefectiveLR,
  title={Defective Lymphotoxin-$\beta$ Receptor-Induced NF-$\kappa$B Transcriptional Activity in NIK-Deficient Mice},
  author={Li Yin and Lin Wu and Holger Wesche and Cora D. Arthur and J. Michael White and David Norman Van Goeddel and Robert D. Schreiber},
  journal={Science},
  year={2001},
  volume={291},
  pages={2162 - 2165}
}
The role of NF-κB–inducing kinase (NIK) in cytokine signaling remains controversial. To identify the physiologic functions of NIK, we disrupted the NIK locus by gene targeting. Although NIK–/– mice displayed abnormalities in both lymphoid tissue development and antibody responses, NIK–/– cells manifested normal NF-κB DNA binding activity when treated with a variety of cytokines, including tumor necrosis factor (TNF), interleukin-1 (IL-1), and lymphotoxin-β (LTβ). However, NIK was selectively… 
Essential Role of NF-κB-Inducing Kinase in T Cell Activation Through the TCR/CD3 Pathway1
TLDR
Critical roles for NIK in setting the threshold for T cell activation are suggested, and partly account for the immunodeficiency in aly mice.
Conditional Deletion of NF-κB–Inducing Kinase (NIK) in Adult Mice Disrupts Mature B Cell Survival and Activation
TLDR
Conditional NIK-knockout mice may be broadly useful for assessing the postdevelopmental and cell-specific roles of NIK and the noncanonical NF-κB pathway in mice.
NF-κB–inducing kinase controls lymphocyte and osteoclast activities in inflammatory arthritis
TLDR
NF-κB–inducing kinase is important in the immune and bone-destructive components of inflammatory arthritis and represents a possible therapeutic target for these diseases.
NF-κB–inducing kinase plays an essential T cell–intrinsic role in graft-versus-host disease and lethal autoimmunity in mice.
TLDR
A critical T cell–intrinsic role for NIK is identified during immune responses and its tight regulation is suggested to be critical for avoiding autoimmunity.
NIK is a component of the EGF/heregulin receptor signaling complexes
TLDR
It is suggested that NIK is a component of the EGF/heregulin receptor signaling complexes and involved in NF-κB activation triggered by these receptors.
NF-κB inducing kinase: a key regulator in the immune system and in cancer.
Cell intrinsic role of NF-κB-inducing kinase in regulating T cell-mediated immune and autoimmune responses
TLDR
Using T cell-conditional NIK knockout mice, it is demonstrated that although NIK is dispensable for thymocyte development, it has a cell-intrinsic role in regulating the homeostasis and function of peripheral T cells.
NF-κB-Inducing Kinase Regulates Selected Gene Expression in the Nod2 Signaling Pathway
TLDR
NIK is linked to the induction of the B-cell chemoattractant known as BLC and it is suggested that this chemokine may play a role in processes initiated by Nod2 activation that lead to improved host defense.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 11 REFERENCES
MAP3K-related kinase involved in NF-KB induction by TNF, CD95 and IL-1
TLDR
The findings indicate that NIK participates in an NF-KB-inducing signalling cascade common to receptors of the TNF/NGF family and to the interleukin-1 type-I receptor.
A cytokine-responsive IκB kinase that activates the transcription factor NF-κB
TLDR
IKK turns out to be the long-sought-after protein kinase that mediates the critical regulatory step in NF-κB activation, and phosphorylates IκBs on the sites that trigger their degradation.
Regulation of interleukin 12 p40 expression through an NF-kappa B half-site
TLDR
This report provides the first characterization of IL-12 p40 gene regulation in macrophages and localizes inducible activity of the promoter to the sequence -122GGGGAATTTTA-132 not previously recognized to bind Rel family transcription factors.
IKK-γ is an essential regulatory subunit of the IκB kinase complex
TLDR
By using a monoclonal antibody against IKK-α, the IKK complex is purify to homogeneity from human cell lines and it is found that IKK is composed of similar amounts of IKK, α and β and two other polypeptides, for which the authors obtained partial sequences.
IκB Kinase-β: NF-κB Activation and Complex Formation with IκB Kinase-α and NIK
TLDR
Overexpression of a catalytically inactive form of IKK-β blocked cytokine-induced NF-κB activation and suggested that an active IκB kinase complex may require three distinct protein kinases.
Tumor necrosis factor (TNF)-mediated kinase cascades: bifurcation of nuclear factor-kappaB and c-jun N-terminal kinase (JNK/SAPK) pathways at TNF receptor-associated factor 2.
TLDR
TNF-induced activation of the transcription factor NF-kappaB and the c-jun N-terminal kinase (JNK/SAPK) requires TNF receptor-associated factor 2 (TRAF2) and this interaction requires the conserved "WKI" motif within the TRAF domain.
NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses.
TLDR
Recently, significant advances have been made in elucidating the details of the pathways through which signals are transmitted to the NF-kappa B:I kappa B complex in the cytosol and their implications for the study of NF-Kappa B.
The Beginning of the End: IκB Kinase (IKK) and NF-κB Activation*
  • M. Karin
  • Biology
    The Journal of Biological Chemistry
  • 1999
TLDR
Three-dimensional structures of NF-kBzIkB ternary complexes were solved, and fascinating structures indicate that the ankyrin repeats of IkBa form a slightly bent cylinder through a stacked arrangement of a-helices that compose their ankyrIn repeats.
...
1
2
...