Defective Immune Complex Degradation by Monocytes in Patients with Systemic Lupus Erythematosus.

@article{Kvai1986DefectiveIC,
  title={Defective Immune Complex Degradation by Monocytes in Patients with Systemic Lupus Erythematosus.},
  author={M{\'a}ria K{\'a}vai and Istv{\'a}n Csip{\"o} and Judit Sonkoly and J{\'o}zsef Csongor and Gyula Szegedi},
  journal={Scandinavian Journal of Immunology},
  year={1986},
  volume={24}
}
The binding of 125I‐labelled anti‐bovine serum albumin (BS A)‐BSA immune complexes (IC). giving a final molar antibody to antigen ratio of 1:1. to monocytes isolated from 18 patients with systemic lupus erythematosus (SLE) and from 10 normal healthy donors was quantitatively investigated. The degradation of the hound IC by the same monocytes was kinetically determined at the same time. The assays were performed on monocyte monolayers. Scatchard plots at 4°C demonstrated that monocytes from… Expand
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The results indicate that despite increased binding of the EA ligand, Fc receptor- mediated phagocytosis is markedly impaired in SLE monocytes, and the dissociation of receptor-ligand binding and receptor-mediated internalization may contribute significantly to the in vivo clearance defect in S LE. Expand
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