Defective IGF2 and IGF1R protein production in embryonic pancreas precedes beta cell mass anomaly in the Goto–Kakizaki rat model of type 2 diabetes

@article{Caldrari2007DefectiveIA,
  title={Defective IGF2 and IGF1R protein production in embryonic pancreas precedes beta cell mass anomaly in the Goto–Kakizaki rat model of type 2 diabetes},
  author={Sophie Cald{\'e}rari and M.-N. Gangnerau and M. Thibault and M.-J. Meile and Nadim Kassis and Carmen {\'A}lvarez and Bernard Portha and Patricia Serradas},
  journal={Diabetologia},
  year={2007},
  volume={50},
  pages={1463-1471}
}
The Goto–Kakizaki (GK) rat is a spontaneous model of type 2 diabetes. Defective beta cell mass detectable in late fetal age precedes the onset of hyperglycaemia. Our hypothesis was that an embryonic IGF production deficiency might be involved in beta cell mass anomaly in the diabetic GK rat. To test this, we evaluated during pancreatic organogenesis: (1) the beta cell development in GK rats on embryonic day (E) 13.5 and E18.5; (2) IGF2 and IGF1 receptor (IGF1R) pancreatic protein production on… CONTINUE READING

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