Defective Guanine Nucleotide Exchange in the Elongation Factor-like 1 (EFL1) GTPase by Mutations in the Shwachman-Diamond Syndrome Protein.

@article{GarcaMrquez2015DefectiveGN,
  title={Defective Guanine Nucleotide Exchange in the Elongation Factor-like 1 (EFL1) GTPase by Mutations in the Shwachman-Diamond Syndrome Protein.},
  author={Adri{\'a}n Garc{\'i}a-M{\'a}rquez and Abril Gijsbers and Eugenio de la Mora and Nuria S{\'a}nchez-Puig},
  journal={The Journal of biological chemistry},
  year={2015},
  volume={290 29},
  pages={17669-78}
}
Ribosome biogenesis is orchestrated by the action of several accessory factors that provide time and directionality to the process. One such accessory factor is the GTPase EFL1 involved in the cytoplasmic maturation of the ribosomal 60S subunit. EFL1 and SBDS, the protein mutated in the Shwachman-Diamond syndrome (SBDS), release the anti-association factor eIF6 from the surface of the ribosomal subunit 60S. Here we report a kinetic analysis of fluorescent guanine nucleotides binding to EFL1… CONTINUE READING
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