Defective FGF signaling causes coloboma formation and disrupts retinal neurogenesis

  title={Defective FGF signaling causes coloboma formation and disrupts retinal neurogenesis},
  author={Shuyi Chen and Hua Li and Karin Gaudenz and Ariel Paulson and Fengli Guo and R. Trimble and Allison Peak and Christopher W. Seidel and Chu-Xia Deng and Yasuhide Furuta and Ting Xie},
  journal={Cell Research},
The optic fissure (OF) is a transient opening on the ventral side of the developing vertebrate eye that closes before nearly all retinal progenitor cell differentiation has occurred. Failure to close the OF results in coloboma, a congenital disease that is a major cause of childhood blindness. Although human genetic studies and animal models have linked a number of genes to coloboma, the cellular and molecular mechanisms driving the closure of the OF are still largely unclear. In this study, we… CONTINUE READING


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