Defective ENaC processing and function in tissue kallikrein-deficient mice.

  title={Defective ENaC processing and function in tissue kallikrein-deficient mice.},
  author={Nicolas Picard and Dominique Eladari and Soumaya El Moghrabi and Carole Plan{\`e}s and Soline Bourgeois and Pascal Houillier and Qing Wang and Michel Burnier and Georges Desch{\^e}nes and Mark A. Knepper and Pierre Meneton and R{\'e}gine Chambrey},
  journal={The Journal of biological chemistry},
  volume={283 8},
An inverse relationship exists between urinary tissue kallikrein (TK) excretion and blood pressure in humans and rodents. In the kidney TK is synthesized in large amounts in the connecting tubule and is mainly released into the urinary fluid where its function remains unknown. In the present study mice with no functional gene coding for TK (TK-/-) were used to test whether the enzyme regulates apically expressed sodium transporters. Semiquantitative immunoblotting of the renal cortex revealed… CONTINUE READING
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