Defective E-cadherin/catenin complexes in human cancer

  title={Defective E-cadherin/catenin complexes in human cancer},
  author={Elisabeth Van Aken and Olivier de Wever and Correia A. da Rocha and Marc Mareel},
  journal={Virchows Archiv},
Cancer is caused by a series of genomic changes leading directly or indirectly to disturbance of growth, differentiation and tissue integrity. Genomic, transcriptional or posttranscriptional alterations of E-cadherin/catenin complexes that are implicated in various steps of cancer development comprise mutational inactivation, transcriptional downregulation of E-cadherin sometimes accompanied by upregulation of N-cadherin, proteolysis of E-cadherin and posttranslational stabilisation of… CONTINUE READING