Defective DROSHA processing contributes to downregulation of MiR-15/-16 in chronic lymphocytic leukemia

@article{Allegra2014DefectiveDP,
  title={Defective DROSHA processing contributes to downregulation of MiR-15/-16 in chronic lymphocytic leukemia},
  author={Domenico Allegra and Vera Bilan and Angela Garding and Hartmut D{\"o}hner and Stephen Stilgenbauer and Florian Kuchenbauer and Daniel Mertens},
  journal={Leukemia},
  year={2014},
  volume={28},
  pages={98-107}
}
The MIR-15A/-16-1 tumor suppressor microRNAs (miRNAs) are deleted in leukemic cells from more than 50% of patients with chronic lymphocytic leukemia (CLL). As these miRNAs are also less abundant in patients without genomic deletion, their downregulation in CLL is likely to be caused by additional mechanisms. We found the primary transcripts (pri-miRNAs) of MIR-15a/-16/-15b to be elevated and processing intermediates (precursor miRNAs) to be reduced in cells from CLL patients (22/38) compared… CONTINUE READING

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