Defective DNA synthesis in human megaloblastic bone marrow: effects of homocysteine and methionine.

@article{Waxman1969DefectiveDS,
  title={Defective DNA synthesis in human megaloblastic bone marrow: effects of homocysteine and methionine.},
  author={S. Waxman and J. Metz and V. Herbert},
  journal={The Journal of clinical investigation},
  year={1969},
  volume={48 2},
  pages={
          284-9
        }
}
  • S. Waxman, J. Metz, V. Herbert
  • Published 1969
  • Biology, Medicine
  • The Journal of clinical investigation
  • In B(12) deficiency, inadequate DNA synthesis seems due in large measure to a block of tetrahydrofolic acid (THFA) regeneration from 5-methyl THFA (via homocysteine transmethylation). In support of the above, homocysteine appears to facilitate and methionine to reduce de novo DNA synthesis. This was measured by the ability of deoxyuridine to suppress thymidine-(3)H uptake into DNA in human bone marrow cultures. The homocysteine effect in B(12)-deficient marrow supports the possibility that… CONTINUE READING
    Evaluation of macrocytosis.
    • 117
    • Open Access

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