Defective DNA-damage repair induced by nuclear lamina dysfunction is a key mediator of smooth muscle cell aging.


Accumulation of DNA damage is a major driving force of normal cellular aging and has recently been demonstrated to hasten the development of vascular diseases such as atherosclerosis. VSMCs (vascular smooth muscle cells) are essential for vessel wall integrity and repair, and maintenance of their proliferative capacity is essential for vascular health. The… (More)
DOI: 10.1042/BST20110703


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