Defective CFTR Expression and Function Are Detectable in Blood Monocytes: Development of a New Blood Test for Cystic Fibrosis

@inproceedings{Sorio2011DefectiveCE,
  title={Defective CFTR Expression and Function Are Detectable in Blood Monocytes: Development of a New Blood Test for Cystic Fibrosis},
  author={Claudio Sorio and Mario Buffelli and Chiara Angiari and Michele Ettorre and Jan Johansson and Marzia Vezzalini and Laura Viviani and Mario Ricciardi and Genny Verz{\'e} and Baroukh Maurice Assael and Paola Melotti},
  booktitle={PloS one},
  year={2011}
}
BACKGROUND Evaluation of cystic fibrosis transmembrane conductance regulator (CFTR) functional activity to assess new therapies and define diagnosis of cystic fibrosis (CF) is cumbersome. It is known that leukocytes express detectable levels of CFTR but the molecule has not been characterized in these cells. In this study we aim at setting up and validating a blood test to evaluate CFTR expression and function in leukocytes. DESCRIPTION Western blot, PCR, immunofluorescence and cell membrane… CONTINUE READING

Figures, Tables, and Topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-10 OF 41 CITATIONS

Macrophage Polarization and Function in Cystic Fibrosis

VIEW 4 EXCERPTS
CITES BACKGROUND & METHODS
HIGHLY INFLUENCED

References

Publications referenced by this paper.
SHOWING 1-10 OF 43 REFERENCES

A cystic fibrosis pancreatic adenocarcinoma cell line.

VIEW 9 EXCERPTS
HIGHLY INFLUENTIAL

CFTR function and prospects for therapy.

VIEW 1 EXCERPT