Defective CD8 T cell responses in aged mice are due to quantitative and qualitative changes in virus-specific precursors.

Abstract

Aging is associated with suboptimal CD8 T cell responses to viral infections. It is not clear whether these poor responses are due to environmental influences or quantitative and qualitative changes in the pool of responding CD8 T cells. Our studies demonstrated several deleterious age-related changes in the pool of Ag-specific CD8 T cells that respond to… (More)
DOI: 10.4049/jimmunol.1101098

Topics

Figures and Tables

Sorry, we couldn't extract any figures or tables for this paper.