Defect of multidrug-resistance 3 gene expression in a subtype of progressive familial intrahepatic cholestasis.

@article{Deleuze1996DefectOM,
  title={Defect of multidrug-resistance 3 gene expression in a subtype of progressive familial intrahepatic cholestasis.},
  author={J. F. Deleuze and Emmanuel Jacquemin and C. Dubuisson and Dani{\`e}le Cresteil and Micheline Dumont and Serge Erlinger and Olivier Bernard and Michelle Hadchouel},
  journal={Hepatology},
  year={1996},
  volume={23 4},
  pages={904-8}
}
Disruption of the murine mdr2 (multidrug-resistance) gene, which encodes a phosphatidylcholine flippase, leads to a hepatic disorder because of loss of biliary phospholipid secretion. Among the hereditary human cholestasis, a subtype of progressive familial intrahepatic cholestasis with high gamma-glutamyltranspeptidase (GGT) serum activity shares histological, biochemical, and genetic features with mice lacking mdr2 gene expression (mdr2 -/- mice). No MDR3 (human mdr2 homolog) messenger RNA… CONTINUE READING
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