Defect of hepatocyte growth factor production by fibroblasts in human pulmonary emphysema.

@article{Plantier2005DefectOH,
  title={Defect of hepatocyte growth factor production by fibroblasts in human pulmonary emphysema.},
  author={Laurent Plantier and Sylvain Marchand-Adam and Jo{\"e}lle Marchal-Somm{\'e} and Guy Les{\'e}che and Michel Fournier and Monique Dehoux and Michel Aubier and Bruno Crestani},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2005},
  volume={288 4},
  pages={L641-7}
}
Pulmonary emphysema results from an excessive degradation of lung parenchyma associated with a failure of alveolar repair. Secretion by pulmonary fibroblasts of hepatocyte growth factor (HGF) and keratinocyte growth factor (KGF) is crucial to an effective epithelial repair after lung injury. We hypothesized that abnormal HGF or KGF secretion by pulmonary fibroblasts could play a role in the development of emphysema. We measured in vitro production of HGF and KGF by human fibroblasts cultured… CONTINUE READING

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