Defect of CARD9 Leads to Impaired Accumulation of Gamma Interferon-Producing Memory Phenotype T Cells in Lungs and Increased Susceptibility to Pulmonary Infection with Cryptococcus neoformans

@article{Yamamoto2014DefectOC,
  title={Defect of CARD9 Leads to Impaired Accumulation of Gamma Interferon-Producing Memory Phenotype T Cells in Lungs and Increased Susceptibility to Pulmonary Infection with Cryptococcus neoformans},
  author={H. Yamamoto and Y. Nakamura and K. Sato and Y. Takahashi and T. Nomura and T. Miyasaka and K. Ishii and H. Hara and N. Yamamoto and E. Kanno and Y. Iwakura and K. Kawakami},
  journal={Infection and Immunity},
  year={2014},
  volume={82},
  pages={1606 - 1615}
}
  • H. Yamamoto, Y. Nakamura, +9 authors K. Kawakami
  • Published 2014
  • Biology, Medicine
  • Infection and Immunity
  • ABSTRACT Caspase recruitment domain-containing protein 9 (CARD9) is an adaptor molecule signal that is critical for NF-κB activation and is triggered through C-type lectin receptors (CLRs), which are pattern recognition receptors that recognize carbohydrate structures. Previous studies have reported that Cryptococcus neoformans, a fungal pathogen that causes meningoencephalitis in AIDS patients, is recognized through some CLRs, such as mannose receptors or DC-SIGN. However, the role of CARD9 in… CONTINUE READING
    42 Citations
    CARD9 Is Required for Classical Macrophage Activation and the Induction of Protective Immunity against Pulmonary Cryptococcosis
    • 4
    • Highly Influenced
    • PDF
    Dectin-3 Recognizes Glucuronoxylomannan of Cryptococcus neoformans Serotype AD and Cryptococcus gattii Serotype B to Initiate Host Defense Against Cryptococcosis
    • 9
    • Highly Influenced
    • PDF
    Dectin-3 recognizes cryptococcal glucuronoxylomannan to initiate host defense against cryptococcosis
    DAP12 Inhibits Pulmonary Immune Responses to Cryptococcus neoformans
    • 5
    • Highly Influenced
    • PDF
    During Aspergillus Infection, Monocyte-Derived DCs, Neutrophils, and Plasmacytoid DCs Enhance Innate Immune Defense through CXCR3-Dependent Crosstalk
    • 3
    • Highly Influenced
    Adaptive Immunity to Cryptococcus neoformans Infections
    • 21
    • PDF
    C-type Lectins in Immunity to Lung Pathogens.
    C-type lectin receptors in tuberculosis: what we know
    • 18
    CARD9 Deficiencies Linked to Impaired Neutrophil Functions Against Phialophoraverrucosa
    • 24

    References

    SHOWING 1-10 OF 56 REFERENCES
    A Novel Role of IL-15 in Early Activation of Memory CD8+ CTL after Reinfection1
    • 52
    • PDF
    Antigen-specific T cell sensitization is impaired in IL-17-deficient mice, causing suppression of allergic cellular and humoral responses. Immunity 17:375–387
    • 2002
    C-type lectin receptors on dendritic cells and langerhans cells
    • 589
    CRYPTOCOCCAL INFECTION AND TH1-TH2 CYTOKINE BALANCE
    • 121
    Card9 controls a non-TLR signalling pathway for innate anti-fungal immunity
    • 723
    Central nervous system infections in the compromised host: a diagnostic approach.
    • B. Cunha
    • Medicine
    • Infectious disease clinics of North America
    • 2001
    • 97