Defect in parathyroid-hormone-induced luminal calcium absorption in connecting tubules of Klotho mice.

@article{Tsuruoka2006DefectIP,
  title={Defect in parathyroid-hormone-induced luminal calcium absorption in connecting tubules of Klotho mice.},
  author={Shuichi Tsuruoka and Kenta Nishiki and Takashi Ioka and Hitoshi Ando and Yuichiro Saito and Masahiko Kurabayashi and Ryozo Nagai and Akio Fujimura},
  journal={Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association},
  year={2006},
  volume={21 10},
  pages={2762-7}
}
BACKGROUND Homozygous Klotho mutant mice (KL(-/-) mice) exhibit multiple phenotypes resembling human ageing. Increases in the ratio of urinary calcium to urinary creatinine (uCa/uCr) and in serum Ca concentration and decreases in urinary Cr excretion and serum parathyroid hormone (PTH) concentration were reported; however, precise information about renal Ca handling was not reported in these animals. METHODS We evaluated the PTH-induced increase in intracellular Ca(2+) concentration ([Ca(2… CONTINUE READING