Defect in insulin action on expression of the muscle/adipose tissue glucose transporter gene in skeletal muscle of type 1 diabetic patients.

@article{YkiJrvinen1992DefectII,
  title={Defect in insulin action on expression of the muscle/adipose tissue glucose transporter gene in skeletal muscle of type 1 diabetic patients.},
  author={Hannele Yki-J{\"a}rvinen and Helena Vuorinen-Markkola and L{\'a}szl{\'o} Kor{\'a}nyi and Raymond E. Bourey and Karen M. Tordjman and Mike M Mueckler and Alan M Permutt and Veikko A. Koivisto},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1992},
  volume={75 3},
  pages={795-9}
}
Recently several members of the glucose transporter family have been identified by molecular cloning techniques. We determined the effect of a 4-h insulin infusion on the expression of the muscle/adipose tissue (GLUT-4) glucose transporter mRNA and protein in 14 insulin-treated type 1 diabetic patients and 15 matched nondiabetic subjects. GLUT-4 mRNA and protein concentrations were determined in muscle biopsies taken before and at the end of the insulin infusion during maintenance of… CONTINUE READING

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