Defect in glycosylation that causes muscular dystrophy.

  title={Defect in glycosylation that causes muscular dystrophy.},
  author={Tamao Endo and Hiroshi Manya},
  journal={Methods in enzymology},
Muscular dystrophies are a diverse group of inherited disorders characterized by progressive muscle weakness and wasting. The dystrophin-glycoprotein complex is composed of alpha-, beta-dystroglycan (DG), dystrophin and some other molecules. alpha- and beta-DG stabilize the sarcolemma by acting as an axis through which the extracellular matrix is tightly linked to the cytoskeleton. The relative molecular weights of alpha-DG differ in different tissues as a result of differential glycosylation… CONTINUE READING


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