Defect in generation of LAK cell activity under oxygen-limited conditions.


In general, the in vitro induction of lymphokine activated killer (LAK) cell activities by interleukin 2 (IL-2) in human peripheral blood mononuclear cells (PMNC) has been performed in an atmosphere of 5% CO2 in air (20% O2), whereas IL-2-induced LAK cell activities are considerably reduced under concentrations of 5% O2 equal to arterial blood oxygen… (More)