Defeating numts: semi-pure mitochondrial DNA from eggs and simple purification methods for field-collected wildlife tissues.

@article{Ibarguchi2006DefeatingNS,
  title={Defeating numts: semi-pure mitochondrial DNA from eggs and simple purification methods for field-collected wildlife tissues.},
  author={Gabriela Ibarguchi and Vicki L. Friesen and Stephen C. Lougheed},
  journal={Genome},
  year={2006},
  volume={49 11},
  pages={1438-50}
}
Mitochondrial DNA (mtDNA) continues to play a pivotal role in phylogeographic, phylogenetic, and population genetic studies. PCR amplification with mitochondrial primers often yields ambiguous sequences, in part because of the co-amplification of nuclear copies of mitochondrial genes (numts) and true mitochondrial heteroplasmy arising from mutations, hybridization with paternal leakage, gene duplications, and recombination. Failing to detect numts or to distinguish the origin of such homologous… CONTINUE READING
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