Default-mode brain dysfunction in mental disorders: A systematic review

@article{Broyd2009DefaultmodeBD,
  title={Default-mode brain dysfunction in mental disorders: A systematic review},
  author={Samantha Broyd and Charmaine Demanuele and Stefan Debener and Suzannah K. Helps and Christopher J. James and Edmund J. S. Sonuga-Barke},
  journal={Neuroscience \& Biobehavioral Reviews},
  year={2009},
  volume={33},
  pages={279-296}
}

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References

SHOWING 1-10 OF 202 REFERENCES
Cingulate-Precuneus Interactions: A New Locus of Dysfunction in Adult Attention-Deficit/Hyperactivity Disorder
Aberrant "default mode" functional connectivity in schizophrenia.
TLDR
Schizophrenia is associated with altered temporal frequency and spatial location of the default mode network, and this network may be under- or overmodulated by key regions, including the anterior and posterior cingulate cortex.
Altered default mode network activity in patient with anxiety disorders: an fMRI study.
Functional disintegration in paranoid schizophrenia using resting-state fMRI
Are anticorrelated networks in the brain relevant to schizophrenia?
TLDR
It is concluded that anticorrelated networks can be viewed as complementary ways of understanding self-monitoring and task performance which extend present models of schizophrenia based on BGTC circuits, however, there are some limitations with regard to the present understanding of brain structures involved in self- monitoring and the lack of asymmetry in the network which may mediate stimulus-independent thought.
Failure to deactivate in the prefrontal cortex in schizophrenia: dysfunction of the default mode network?
TLDR
Patients with schizophrenia show both failure to activate and failure to deactivate during performance of a working memory task, including an area in the anterior prefrontal/anterior cingulate cortex that corresponds to one of the two midline components of the ‘default mode network’ implicated in functions related to maintaining one's sense of self.
Default-mode network activity distinguishes Alzheimer's disease from healthy aging: Evidence from functional MRI
TLDR
A goodness-of-fit analysis applied at the individual subject level suggests that activity in the default-mode network may ultimately prove a sensitive and specific biomarker for incipient AD.
Failing to deactivate: resting functional abnormalities in autism.
TLDR
It is speculated that the lack of deactivation in the autism group is indicative of abnormal internally directed processes at rest, which may be an important contribution to the social and emotional deficits of autism.
Spontaneous attentional fluctuations in impaired states and pathological conditions: A neurobiological hypothesis
...
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