Deeply conserved chordate noncoding sequences preserve genome synteny but do not drive gene duplicate retention.

@article{Hufton2009DeeplyCC,
  title={Deeply conserved chordate noncoding sequences preserve genome synteny but do not drive gene duplicate retention.},
  author={Andrew L. Hufton and Susanne Mathia and H{\'e}l{\`e}ne Braun and Udo Georgi and Hans Lehrach and Martin Vingron and Albert J. Poustka and Georgia Panopoulou},
  journal={Genome research},
  year={2009},
  volume={19 11},
  pages={
          2036-51
        }
}
Animal genomes possess highly conserved cis-regulatory sequences that are often found near genes that regulate transcription and development. Researchers have proposed that the strong conservation of these sequences may affect the evolution of the surrounding genome, both by repressing rearrangement, and possibly by promoting duplicate gene retention. Conflicting data, however, have made the validity of these propositions unclear. Here, we use a new computational method to identify… CONTINUE READING
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