• DOI:10.1016/j.jsb.2016.07.006
Corpus ID: 3908505

DeepPicker: a Deep Learning Approach for Fully Automated Particle Picking in Cryo-EM

@article{Wang2016DeepPickerAD,
  title={DeepPicker: a Deep Learning Approach for Fully Automated Particle Picking in Cryo-EM},
  author={Feng Wang and Huichao Gong and Gaochao liu and Meijing Li and C. Yan and Tian Xia and X. Li and Jianyang Zeng},
  journal={Journal of structural biology},
  year={2016},
  volume={195 3},
  pages={
          325-336
        }
}

• Feng Wang, Huichao Gong, +5 authors Jianyang Zeng
• Published 2016
• Computer Science, Medicine, Mathematics, Biology
• Journal of structural biology

Particle picking is a time-consuming step in single-particle analysis and often requires significant interventions from users, which has become a bottleneck for future automated electron cryo-microscopy (cryo-EM. [...] Key Result Tests on the recently-published cryo-EM data of three complexes have demonstrated that our deep learning based scheme can successfully accomplish the human-level particle picking process and identify a sufficient number of particles that are comparable to those picked manually by…Expand

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