DeepChrome: deep-learning for predicting gene expression from histone modifications

  title={DeepChrome: deep-learning for predicting gene expression from histone modifications},
  author={Ritambhara Singh and Jack Lanchantin and Gabriel Robins and Yanjun Qi},
  volume={32 17},
MOTIVATION Histone modifications are among the most important factors that control gene regulation. Computational methods that predict gene expression from histone modification signals are highly desirable for understanding their combinatorial effects in gene regulation. This knowledge can help in developing 'epigenetic drugs' for diseases like cancer. Previous studies for quantifying the relationship between histone modifications and gene expression levels either failed to capture… 

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