DeepCEL0 for 2D Single Molecule Localization in Fluorescence Microscopy

  title={DeepCEL0 for 2D Single Molecule Localization in Fluorescence Microscopy},
  author={Pasquale Cascarano and Maria Colomba Comes and Andrea Sebastiani and Arianna Mencattini and Elena Loli Piccolomini and Eugenio Martinelli},
MOTIVATION In fluorescence microscopy, Single Molecule Localization Microscopy (SMLM) techniques aim at localizing with high precision high density fluorescent molecules by stochastically activating and imaging small subsets of blinking emitters. Super Resolution (SR) plays an important role in this field since it allows to go beyond the intrinsic light diffraction limit. RESULTS In this work, we propose a deep learning-based algorithm for precise molecule localization of high density frames… 

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