Deep-vein thrombosis and subsequent onset of cancer.


Two study groups were identified in a total of 250 patients with confirmed deep-vein thrombosis treated at the University of Padua, Padua, Italy, drawn from 1159 consecutive patients seen 1985 to 1991 for suspected thrombosis. Out of a regional population of 350,000, general practitioners referred all cases with suspected deep-vein thrombosis to the treatment center in Padua. The diagnosis was confirmed by venography in 342 patients. From this series 92 patients were excluded, 30 because of a prior episode of deep-vein thrombosis, 49 because of assodated malignant disease prior to referral, 3 were unwilling to be followed, and 5 were lost to follow-up. Routine examination at hospital admission revealed findings of possible malignant disease in 76 patients, but further evaluation confirmed the presence of cancer in only 5 patients, who were also excluded. The remaining 250 patients were divided into two groups: 105 patients with one or more of the following risk factors for their thrombosis strong family histor~ lupus, deficiency of antithrombin III or protein C or S, trauma to a lower limb, prolonged immobilization due to medical or surgical disorders, pregnancy or the puerperal state; and 145 patients without any of these risk factors. The term, secondary deep-vein thrombosis, was applied to the group of patients with one of the risk factors listed, and the term idiopathic deep-vein thrombosis was used to characterize the group of patients with no risk factor present. In the idiopathic group there were 87 males and 58 females, in the secondary group, 55 males and 50 females. Mean

Cite this paper

@article{Singer1992DeepveinTA, title={Deep-vein thrombosis and subsequent onset of cancer.}, author={Richard B. Singer}, journal={Journal of insurance medicine}, year={1992}, volume={24 4}, pages={275-7} }