Deep vein thrombosis and pulmonary embolism

@article{Nisio2017DeepVT,
  title={Deep vein thrombosis and pulmonary embolism},
  author={Marcello Di Nisio and Nick van Es and Harry R B{\"u}ller},
  journal={The Lancet},
  year={2017},
  volume={388},
  pages={3060-3073}
}

Deep Venous Thrombosis and Pulmonary Embolism

TLDR
This chapter reviews the diagnosis of PE and DVT including different testing modalities, and different therapies are discussed such as thrombolytics, anticoagulation, and prevention of venous thrombosis.

Deep Venous Thrombosis and Venous Thromboembolism Prevention in the Neurocritical Care Unit

TLDR
The available evidence supports the use of mechanical and chemical VTE prophylaxis as beneficial in reducing the risk of developing DVT and PE; unfortunately, therisk of hemorrhagic complications when starting chemical prophYLaxis remains a substantial concern for health-care providers.

Venous Thromboembolism: Role of the Clinical Laboratory in Diagnosis and Management.

BACKGROUND Venous thromboembolism (VTE) is the third most common cause of cardiovascular illness and is projected to double in incidence by 2050. It is a spectrum of disease that includes deep venous

Development and validation of a prediction model to estimate risk of acute pulmonary embolism in deep vein thrombosis patients

TLDR
A novel prediction model is developed to identify patients with different risks for APE in DVT patients, which may be useful for quickly estimating the probability of APE before obtaining definitive test results and speeding up emergency management processes.

Advanced Therapies for Acute Pulmonary Embolism: A Focus on Catheter-Based Therapies and Future Directions

TLDR
Emerging strategies utilizing adjunctive mechanical circulatory support may improve outcomes in the highest risk patients, providing stabilization prior to definitive therapy and potentially obviating the need for invasive measures.

Neurologic complications of venous thromboembolism.

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The current place of direct oral anticoagulants in the prevention/treatment of venous thromboembolism

TLDR
For acute VTE treatment and secondary prevention, DOACs are recommended as the first-line therapy in the general population and should be made mainly according to patient characteristics and pharmacokinetic properties of the drug.
...

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TLDR
The strengths and weaknesses of venous ultrasonography are considered in patients with the five clinical presentations of suspected venous thromboembolism and the criteria used to diagnose thrombosis often vary among examiners.

Natural History of Venous Thromboembolism

TLDR
After a course of treatment, the risk of recurrent thrombosis is higher in patients without reversible risk factors, in patients with cancer, and in those with prothrombotic biochemical abnormalities such as antiphospholipid antibodies and homozygous factor V Leiden.

Thromboembolic resolution assessed by CT pulmonary angiography after treatment for acute pulmonary embolism.

TLDR
The incidence of residual thrombotic obstruction following treatment for PE is considerably lower than currently anticipated, and these findings do not support the routine use of follow-up CTPA-imaging in patients treated for acute PE.

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TLDR
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Clinical Impact of Bleeding in Patients Taking Oral Anticoagulant Therapy for Venous Thromboembolism

TLDR
A meta-analysis of studies involving patients with venous thromboembolism who received at least 3 months of oral anticoagulant therapy with a target international normalized ratio (INR) of 2.0 to 3.0 obtained reliable estimates of the clinical impact of anticogulant-related bleeding.

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TLDR
Pros and cons of anticoagulant treatment in the presence of symptomatic distal deep vein thrombosis are discussed to discuss pros and cons and randomized trials are urgently needed.

D-dimer to guide the duration of anticoagulation in patients with venous thromboembolism: a management study.

TLDR
Serial D-dimer measurement is suitable in clinical practice for the identification of VTE patients in whom anticoagulation can be safely discontinued, and can identify subjects at low recurrence risk.

The diagnosis of symptomatic recurrent pulmonary embolism and deep vein thrombosis: guidance from the SSC of the ISTH

This document is intended to give clinical guidance for the diagnosis of symptomatic recurrent pulmonary embolism (PE) and/or deep vein thrombosis (DVT). We define recurrent PE and DVT as those

Treatment of venous thromboembolism.

TLDR
The mainstay of VTE treatment is anticoagulation, while interventions such as thrombolysis and inferior vena cava filters are reserved for limited circumstances and better prediction tools for major hemorrhage are needed.
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