Deep-transcriptome and ribonome sequencing redefines the molecular networks of pluripotency and the extracellular space in human embryonic stem cells.

@article{Kolle2011DeeptranscriptomeAR,
  title={Deep-transcriptome and ribonome sequencing redefines the molecular networks of pluripotency and the extracellular space in human embryonic stem cells.},
  author={Gabriel Kolle and Jill L Shepherd and Brooke Gardiner and Karin S. Kassahn and Nicole Cloonan and David L. A. Wood and Ehsan Nourbakhsh and Darrin F. Taylor and Shivangi Wani and Hun S. Chy and Qi Zhou and Kevin Mckernan and Scott Kuersten and Andrew L Laslett and Sean M. Grimmond},
  journal={Genome research},
  year={2011},
  volume={21 12},
  pages={2014-25}
}
Recent RNA-sequencing studies have shown remarkable complexity in the mammalian transcriptome. The ultimate impact of this complexity on the predicted proteomic output is less well defined. We have undertaken strand-specific RNA sequencing of multiple cellular RNA fractions (>20 Gb) to uncover the transcriptional complexity of human embryonic stem cells (hESCs). We have shown that human embryonic stem (ES) cells display a high degree of transcriptional diversity, with more than half of active… CONTINUE READING
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