Deep sequencing to infer HIV-1 co-receptor usage: application to three clinical trials of maraviroc in treatment-experienced patients.

@article{Swenson2011DeepST,
  title={Deep sequencing to infer HIV-1 co-receptor usage: application to three clinical trials of maraviroc in treatment-experienced patients.},
  author={Luke C. Swenson and Theresa Mo and Winnie W. Y Dong and Xiaoyin Zhong and Conan K. Woods and Mark A. Jensen and Alexander Thielen and Douglass Chapman and Marilyn Lewis and Ian M James and Jayvant R. Heera and Hern{\'a}n Valdez and P. Richard Harrigan},
  journal={The Journal of infectious diseases},
  year={2011},
  volume={203 2},
  pages={237-45}
}
BACKGROUND The Maraviroc versus Optimized Therapy in Viremic Antiretroviral Treatment-Experienced Patients (MOTIVATE) studies compared maraviroc versus placebo in treatment-experienced patients with CCR5-using (R5) human immunodeficiency virus type 1 (HIV-1), screened using the original Trofile assay. A subset with non-R5 HIV infection entered the A4001029 trial. We retrospectively examined the performance of a genotypic tropism assay based on deep sequencing of the HIV env V3 loop in… CONTINUE READING
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