Deep sequencing reveals abundant noncanonical retroviral microRNAs in B-cell leukemia/lymphoma.

@article{Rosewick2013DeepSR,
  title={Deep sequencing reveals abundant noncanonical retroviral microRNAs in B-cell leukemia/lymphoma.},
  author={Nicolas Rosewick and M{\'e}lanie Momont and Keith F. Durkin and Hideki Takeda and Florian Caiment and Yvette Cleuter and C{\'e}line Vernin and Franck Mortreux and E Wattel and Ars{\`e}ne Burny and Michel Andre Georges and Anne Van den Broeke},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2013},
  volume={110 6},
  pages={
          2306-11
        }
}
Viral tumor models have significantly contributed to our understanding of oncogenic mechanisms. How transforming delta-retroviruses induce malignancy, however, remains poorly understood, especially as viral mRNA/protein are tightly silenced in tumors. Here, using deep sequencing of broad windows of small RNA sizes in the bovine leukemia virus ovine model of leukemia/lymphoma, we provide in vivo evidence of the production of noncanonical RNA polymerase III (Pol III)-transcribed viral microRNAs… CONTINUE READING

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