Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs.

@article{Jima2010DeepSO,
  title={Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs.},
  author={Dereje D. Jima and Jenny Zhang and Cassandra Jacobs and Kristy L Richards and Cherie Hilborn Dunphy and William W. L. Choi and Wing-yan Au and Gopesh Srivastava and Magdalena B. Czader and David Alan Rizzieri and Anand S. Lagoo and Patricia L. Lugar and Karen P. Mann and Christopher R Flowers and Leon Bernal-Mizrachi and Kikkeri N Naresh and Andrew M Evens and Leo I Gordon and Micah Luftig and Daphne R. Friedman and J Brice Weinberg and Michael Allen Thompson and Javed I Gill and Qingquan Liu and Tam How and Vladimir Grubor and Yuan Gao and Amee A Patel and Han Wu and Jun Zhu and Gerard C. Blobe and Peter E Lipsky and Amy Chadburn and Sandeep S Dave},
  journal={Blood},
  year={2010},
  volume={116 23},
  pages={e118-27}
}
A role for microRNA (miRNA) has been recognized in nearly every biologic system examined thus far. A complete delineation of their role must be preceded by the identification of all miRNAs present in any system. We elucidated the complete small RNA transcriptome of normal and malignant B cells through deep sequencing of 31 normal and malignant human B-cell samples that comprise the spectrum of B-cell differentiation and common malignant phenotypes. We identified the expression of 333 known… CONTINUE READING