Deep sequencing of non-ribosomal peptide synthetases and polyketide synthases from the microbiomes of Australian marine sponges

@article{Woodhouse2013DeepSO,
  title={Deep sequencing of non-ribosomal peptide synthetases and polyketide synthases from the microbiomes of Australian marine sponges},
  author={Jason Nicholas Woodhouse and Lu Fan and Mark V. Brown and Torsten Thomas and Brett A Neilan},
  journal={The ISME Journal},
  year={2013},
  volume={7},
  pages={1842-1851}
}
The biosynthesis of non-ribosomal peptide and polyketide natural products is facilitated by multimodular enzymes that contain domains responsible for the sequential condensation of amino and carboxylic subunits. These conserved domains provide molecular targets for the discovery of natural products from microbial metagenomes. This study demonstrates the application of tag-encoded FLX amplicon pyrosequencing (TEFAP) targeting non-ribosomal peptide synthetase (NRPS) and polyketide synthase (PKS… CONTINUE READING
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