Deep sequencing of microRNA precursors reveals extensive 3' end modification.

  title={Deep sequencing of microRNA precursors reveals extensive 3' end modification.},
  author={Martin A. Newman and Vidya Mani and Scott M. Hammond},
  volume={17 10},
MicroRNAs (miRNAs) are small, noncoding RNAs that post-transcriptionally regulate gene expression. An emerging mechanism to control miRNA production is the addition of an oligo-uridine tail to the 3' end of the precursor miRNA. This has been demonstrated for the Let-7 family of miRNAs in embryonic cells. Additionally, nontemplated nucleotides have been found on mature miRNA species, though in most cases it is not known if nucleotide addition occurs at the precursor step or at the mature miRNA… CONTINUE READING
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