Deep sequencing of gastric carcinoma reveals somatic mutations relevant to personalized medicine

@inproceedings{Holbrook2011DeepSO,
  title={Deep sequencing of gastric carcinoma reveals somatic mutations relevant to personalized medicine},
  author={Joanna D. Holbrook and Joel S. Parker and Kathleen T Gallagher and Wendy S. Halsey and Ashley M. Hughes and Victor J. Weigman and Peter F. Lebowitz and Rakesh Kumar},
  booktitle={Journal of Translational Medicine},
  year={2011}
}
Globally, gastric cancer is the second most common cause of cancer-related death, with the majority of the health burden borne by economically less-developed countries. Here, we report a genetic characterization of 50 gastric adenocarcinoma samples, using affymetrix SNP arrays and Illumina mRNA expression arrays as well as Illumina sequencing of the coding regions of 384 genes belonging to various pathways known to be altered in other cancers. Genetic alterations were observed in the WNT… CONTINUE READING
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