Deep sequencing of RNA from immune cell-derived vesicles uncovers the selective incorporation of small non-coding RNA biotypes with potential regulatory functions

@inproceedings{Hoen2012DeepSO,
  title={Deep sequencing of RNA from immune cell-derived vesicles uncovers the selective incorporation of small non-coding RNA biotypes with potential regulatory functions},
  author={Esther N. M. Nolte-’t Hoen and Henk P. J. Buermans and Maaike Waasdorp and Willem Stoorvogel and Marca H M Wauben and Peter A. C. ’t Hoen},
  booktitle={Nucleic acids research},
  year={2012}
}
Cells release RNA-carrying vesicles and membrane-free RNA/protein complexes into the extracellular milieu. Horizontal vesicle-mediated transfer of such shuttle RNA between cells allows dissemination of genetically encoded messages, which may modify the function of target cells. Other studies used array analysis to establish the presence of microRNAs and mRNA in cell-derived vesicles from many sources. Here, we used an unbiased approach by deep sequencing of small RNA released by immune cells… CONTINUE READING
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