Deep sequencing-based transcriptome profiling analysis of Chlamys farreri exposed to benzo[a]pyrene.

@article{Cai2014DeepST,
  title={Deep sequencing-based transcriptome profiling analysis of Chlamys farreri exposed to benzo[a]pyrene.},
  author={Yuefeng Cai and Luqing Pan and Fengxiao Hu and Qian Jin and Tong Liu},
  journal={Gene},
  year={2014},
  volume={551 2},
  pages={261-70}
}
Whole-genome transcriptome measurements are pivotal for characterizing molecular mechanisms of chemicals and predicting toxic classes, such as genotoxicity and carcinogenicity, from in vitro and in vivo assays. We analyzed the dynamic defense transcriptome responsive to Chlamys farreri upon exposure to benzo[a]pyrene (BaP) using a digital gene expression (DGE) approach. Following exposure, 251 and 177 genes were up-regulated, and 142 and 300 genes were down-regulated at 3 days post-exposure and… CONTINUE READING