Deep phenotyping of cardiac function in heart transplant patients using cardiovascular system models

  title={Deep phenotyping of cardiac function in heart transplant patients using cardiovascular system models},
  author={Amanda L. Colunga and Karam G. Kim and N. Payton Woodall and Todd F. Dardas and John H. Gennari and Mette Sofie Olufsen and Brian E. Carlson},
  journal={The Journal of Physiology},
Right heart catheterization data from clinical records of heart transplant patients are used to identify patient‐specific models of the cardiovascular system. These patient‐specific cardiovascular models represent a snapshot of cardiovascular function at a given post‐transplant recovery time point. This approach is used to describe cardiac function in 10 heart transplant patients, five of which had multiple right heart catheterizations allowing an assessment of cardiac function over time. These… 

Phenotyping heart failure using model-based analysis and physiology-informed machine learning

The results suggest that cardiovascular system modeling of standard clinical data is able to phenotype and group HFpEF as different subdiagnoses, possibly elucidating patient-specific treatment strategies.

Phenotyping heart failure using model‐based analysis and physiology‐informed machine learning

The results suggest that modelling of the cardiovascular system and optimizing to standard clinical data can designate subgroups of HFpEF as separate phenotypes, possibly elucidating patient‐specific treatment strategies.

A closer look at physiological indicators of cardiovascular function post‐transplantation

A patient-specific computational methodology is used which incorporates clinical measures and is used to predict time-dependent measures of pressure, flow, and volume, as well as mechanistic measures, many of which presented are not easily measured in the clinic.

Parameter inference in a computational model of hemodynamics in pulmonary hypertension

Results show that additional waveform data enables accurate calibration of the right atrial reservoir and pump function across the PH cohort, and estimated parameters agree with previous, non-modeling studies, supporting this type of analysis in translational PH research.

Estimation of Pulmonary Arterial Pressure Using Simulated Non-Invasive Measurements and Gradient-Based Optimization Techniques

This work proposes an approach to infer pulmonary arterial pressure based on scientific machine learning techniques and non-invasive, clinically available measurements and highlights the potential of the proposed model to determine pulmonary pressure for diseased heart valves and pulmonary hypertensive conditions.

An in-silico analysis of experimental designs to study ventricular function: A focus on the right ventricle

In-vivo studies of pulmonary vascular disease and pulmonary hypertension (PH) have provided key insight into the progression of right ventricular (RV) dysfunction. Additional in-silico experiments

Biventricular interaction during acute left ventricular ischemia in mice: a combined in-vivo and in-silico approach

It is shown that a model with both biventricular mechanical interaction and systems level cardiovascular dynamics can quantitatively reproduce in-vivo data and qualitatively match prior findings from animal studies on LV ischemia.

Non-invasive estimation of left ventricle elastance using a multi-compartment lumped parameter model and gradient-based optimization with forward-mode automatic differentiation

Accurate estimates of left ventricle elastances based on non-invasive measurements are required for clinical decision-making during treatment of valvular diseases. The present study proposes a



Role of cardiac power in heart failure

Cardiac pumping capability can be defined as the cardiac power output (CPOmax) achieved by the heart during maximal stimulation, which is a direct indicator of overall cardiac function and a most powerful predictor of prognosis for patients with chronic heart failure.

Cardiac power is the strongest hemodynamic correlate of mortality in cardiogenic shock: a report from the SHOCK trial registry.

Time course of resolution of pulmonary hypertension and right ventricular remodeling after orthotopic cardiac transplantation.

There is rapid resolution of moderately elevated pulmonary arterial pressures after cardiac transplantation, and echocardiographic analysis showed that transplant recipients had an enlarged right ventricle on day 1 after surgery, and a volume overload contraction pattern and tricuspid regurgitation was present in the majority.

Patient-specific modelling of head-up tilt.

A patient-specific model that uses heart rate as an input to fit the dynamic changes in arterial blood pressure data during HUT is presented, which estimates physiologically reasonable values for arterial and venous blood pressures, blood volumes and cardiac output for which data are not available.

Evolution of hemodynamics after orthotopic heart and heart-lung transplantation: early restrictive patterns persisting in occult fashion.

A characteristic evolvement of hemodynamics in heart and heart-lung transplants that mimic dynamics associated with restrictive myocardial disease is documented.

Long-term hemodynamic follow-up of cardiac transplant patients treated with cyclosporine and prednisone.

Mild-to-moderate hemodynamic abnormalities are common in asymptomatic cardiac transplant patients receiving cyclosporine and prednisone, and tended to resolve or improve in the five patients restudied 2 years after transplantation.

Non-invasive evaluation of orthotopic heart transplant rejection by echocardiography.

  • J. SunI. Abdalla Mario J. Garcia
  • Medicine
    The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation
  • 2005

Impaired left ventricular filling due to right-to-left ventricular interaction in patients with pulmonary arterial hypertension.

In PAH patients, ventricular interaction mediated by the interventricular septum impairs left ventricular filling, contributing to decreased stroke volume.

Reliability of Tissue Doppler Wall Motion Monitoring After Heart Transplantation for Replacement of Invasive Routine Screenings by Optimally Timed Cardiac Biopsies and Catheterizations

Without diastolic parameter changes, acute rejection can be practically excluded, and serial PW-TDI can save patients from routine EMBs.