Deep percutaneous penetration into muscles and joints.

  title={Deep percutaneous penetration into muscles and joints.},
  author={Christine M. Lee and Howard Ira Maibach},
  journal={Journal of pharmaceutical sciences},
  volume={95 7},
The transdermal absorption of drugs and its subsequent deep tissue delivery is a complex process, with many factors influencing the penetration mechanisms. Nonsteroidal antiinflammatory drugs (NSAIDs) are widely used in the treatment of joint and muscle diseases. However, the dangers associated with oral medications highlight the need for alternative methods of targeting and retaining drugs; one such means is through topical delivery. The drug's lipophilicity, permeability, and fraction unbound… CONTINUE READING
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