Deep imaging in highly scattering media by combining reflection matrix measurement with Bessel-like beam based optical coherence tomography.

@article{Yang2018DeepII,
  title={Deep imaging in highly scattering media by combining reflection matrix measurement with Bessel-like beam based optical coherence tomography.},
  author={Qiang Yang and Yusi Miao and Tiancheng Huo and Yan Li and Emon Heidari and Jiang Zhu and Zhongping Chen},
  journal={Applied physics letters},
  year={2018},
  volume={113 1},
  pages={
          011106
        }
}
Multiple scattering in biomedical tissue limits the imaging depth within a range of 1-2 mm for conventional optical imaging techniques. To extend the imaging depth into the scattering medium, a computational method based on the reflection matrix measurement has been developed to retrieve the singly back-scattered signal light from the dominant detrimental multiple-scattered background. After applying singular value decomposition on the measured matrix in the post-process, the target image… 

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References

SHOWING 1-10 OF 21 REFERENCES
Smart optical coherence tomography for ultra-deep imaging through highly scattering media
TLDR
By combining a matrix discrimination of ballistic waves and iterative time reversal, this work shows an extension of the imaging-depth limit by at least a factor of 2 compared to optical coherence tomography.
Spatial Filter Based Bessel-Like Beam for Improved Penetration Depth Imaging in Fluorescence Microscopy
TLDR
This study uses a Bessel-like beam in-conjugation with an orthogonal detection system to achieve depth imaging and demonstrates a penetration depth that extends up to 650 µm, which will advance the field of fluorescence imaging and deep nano-particle tracking.
Depth-of-focus extension in optical coherence tomography via multiple aperture synthesis
In this paper, we report what we believe is a novel technique to overcome the depth-of-focus (DOF) limitation in optical coherence tomography (OCT). Using confocal optics on a sample arm, we scanned
Extended depth of focus for coherence-based cellular imaging.
TLDR
A fiber optics system that generates a coaxially focused multimode (CAFM) beam for depth of focus (DOF) extension is introduced, enabling cross-sectional imaging of biological tissues with clearly resolved cellular and subcellular structures over more than a 400 μm depth range.
Detection of multiple scattering in optical coherence tomography using the spatial distribution of Stokes vectors.
TLDR
A polarization-sensitive method that shows the potential to detect multiply scattered light more directly, based on the degree to which the detected polarization state at any given image point is correlated with the mean state over the surrounding region is presented.
Contrast limits of coherence-gated imaging in scattering media.
TLDR
The imaging contrast is limited by multiple scattering and speckle effects in high-scattering media, and the measured effective penetration depth of optical coherence tomography is approximately equal to six mean free paths under the experimental conditions of a numerical aperture and a scattering anisotropy of approximately 0.8.
4D optical coherence tomography-based micro-angiography achieved by 1.6-MHz FDML swept source.
TLDR
An ultra-high-speed swept-source optical coherence tomography (OCT) system based on a 1310-nm Fourier domain mode-locking laser is used to achieve optical micro-angiography (OMAG) of microcirculatory tissue beds in vivo.
In-vivo retinal imaging with off-axis full-field time-domain optical coherence tomography.
TLDR
A novel motion-insensitive approach to FF-OCT is presented, which introduces path-length differences between the reference and the sample light in neighboring pixels using an off-axis reference beam, and the temporal carrier frequency in scanned time-domain OCT is replaced by a spatial carrier frequency.
Focus defect and dispersion mismatch in full-field optical coherence microscopy.
TLDR
Experimental methods that have been implemented in FFOCM to minimize the adverse effects of these phenomena are summarized and compared.
Optical coherence tomography for ultrahigh resolution in vivo imaging
TLDR
Optical coherence tomography functions as a type of 'optical biopsy' to provide cross-sectional images of tissue structure on the micron scale and is a promising imaging technology because it can provide images of tissues in situ and in real time, without the need for excision and processing of specimens.
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