Deep hypothermia and rewarming alters glutamate levels and glycogen content in cultured astrocytes.

@article{Bissonnette1999DeepHA,
  title={Deep hypothermia and rewarming alters glutamate levels and glycogen content in cultured astrocytes.},
  author={Bruno Bissonnette and Luc Pellerin and Patrick Ravussin and V B Daven and Pierre J. Magistretti},
  journal={Anesthesiology},
  year={1999},
  volume={91 6},
  pages={1763-9}
}
BACKGROUND Deep hypothermia has been associated with an increased incidence of postoperative neurologic dysfunction after cardiac surgery in children. Recent studies suggest an excitotoxic mechanism involving overstimulation of glutamate receptors. Extracellular glutamate uptake occurs primarily by astrocytes. Astrocytes also store glycogen, which may be used to sustain the energy-consuming glutamate uptake. Extracellular glutamate and glycogen content were studied during temperature changes… CONTINUE READING