Deep homology and the origins of evolutionary novelty

@article{Shubin2009DeepHA,
  title={Deep homology and the origins of evolutionary novelty},
  author={Neil H. Shubin and Clifford J. Tabin and Sean B. Carroll},
  journal={Nature},
  year={2009},
  volume={457},
  pages={818-823}
}
Do new anatomical structures arise de novo, or do they evolve from pre-existing structures? Advances in developmental genetics, palaeontology and evolutionary developmental biology have recently shed light on the origins of some of the structures that most intrigued Charles Darwin, including animal eyes, tetrapod limbs and giant beetle horns. In each case, structures arose by the modification of pre-existing genetic regulatory circuits established in early metazoans. The deep homology of… 
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